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Abstract #2214

QSM susceptibility patterns and their clinical implications

Kelly Gillen1, Mayyan Mubarak2, Shun Zhang1, Somiah Dahlawi2, Thanh D Nguyen1, David Pitt2, and Yi Wang1

1Radiology, Weill Cornell Medical College, New York, NY, United States, 2Neurology, Yale University, New Haven, CT, United States

Multiple sclerosis is an autoimmune disorder characterized by focal inflammatory demyelination. We combined quantitative susceptibility mapping (QSM) with histopathology on MS autopsy tissue to identify chronic activation of iron-positive macrophages/microglia. We demonstrate that the QSM susceptibility pattern gives insight into the lesion inflammatory state. Only rim positive lesions indicate smoldering inflammation in the presence of iron, and therefore are of particular relevance in the clinic.

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