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Abstract #2230

Multiple Interleaved Mode Saturation (MIMOSA) for B1+ inhomogeneity mitigation in chemical exchange saturation transfer.

Andrzej Liebert1, Moritz Zaiss2, Rene Gumbrecht3, Benjamin Schmitt4, Peter Linz1, Frederik B. Laun1, Michael Uder1, and Armin M. Nagel1

1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Siemens Healthcare Pty Ltd, Sydney, Australia

Due to high sensitivity to B1+-inhomogeneities, Chemical Exchange Saturation Transfer MRI requires a correction or mitigation of the B1+-inhomogeneity at ultra-high magnetic field strengths (B0 ≥ 7 Tesla). A novel approach for mitigation of B1+-inhomogeneity effects that affects the saturation process is presented. The method employs two interleaved excitation modes during the saturation pulse train. Simulations show a decrease of the relative difference of the MTRRex metric caused by B1+ inhomogeneity. This “Multiple Interleaved Mode Saturation” scheme leads to improved homogeneity in both, phantom and in vivo measurements at 7 Tesla.

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