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Abstract #2240

Steady-state CEST-MRI using a reduced saturation period

Johannes Breitling1, Steffen Goerke1, Jan-Eric Meissner1, Andreas Korzowski1, Patrick Schuenke1, Mark E. Ladd1, and Peter Bachert1

1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, we propose a novel approach to determine the steady-state of CEST experiments without the application of prolonged saturation periods. This is achieved by numerically calculating the steady-state from a measurement with a reduced saturation period (in the order of the water proton T1). This may allow quantitative CEST measurements, capable of providing information about pH and metabolite concentrations, in a reasonable and clinical relevant time frame.

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