Meeting Banner
Abstract #2251

Quantitative estimation of sub-voxel fat and water fractions based on two T2-component fitting in calf muscle.

Jannette Nassar1, Dvir Radunsky1, Noam Omer1, Yann Le Fur2, David Bendahan2, and Noam Ben-Eliezer1,3,4

1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 3Center for Advanced Imaging Innovation and Research, New York University, New York, NY, United States, 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

T2 relaxation is an effective biomarker for muscle pathology including inflammation, necrosis, or fatty infiltration. Accurate quantification of T2 values, however, is hampered due to the inherent bias of rapid multi-SE protocols by stimulated echoes. Recently, we introduced the echo modulation curve (EMC) algorithm, which successfully overcomes this problem and provide accurate T2 values that are stable across scanners and scan-settings. In this work, we present extension of the EMC algorithm for two component fitting, water and fat, allowing to quantify the sub-voxel infiltration of fat into the muscle, along with the corresponding T2 value of each component.

This abstract and the presentation materials are available to members only; a login is required.

Join Here