T2 relaxation is an effective biomarker for muscle pathology including inflammation, necrosis, or fatty infiltration. Accurate quantification of T2 values, however, is hampered due to the inherent bias of rapid multi-SE protocols by stimulated echoes. Recently, we introduced the echo modulation curve (EMC) algorithm, which successfully overcomes this problem and provide accurate T2 values that are stable across scanners and scan-settings. In this work, we present extension of the EMC algorithm for two component fitting, water and fat, allowing to quantify the sub-voxel infiltration of fat into the muscle, along with the corresponding T2 value of each component.
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