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Abstract #2254

Evaluation of A Method for Simultaneous in vivo Measurements of Blood T1 and T2

Jialu Zhang1,2,3, Dingxin Wang3, Xiaotong Zhang1,2, Lynn E. Eberly 4, Gregory J. Metzger3, Donald R. Dengel5, David Tupper6, Anne M. Murray7, and Xiufeng Li3

1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China, 2College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, 4Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States, 5Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, 6Neuropsychology Section, Hennepin County Medical Center, Minneapolis, MN, United States, 7Berman Center for Clinical Research, Hennepin County Medical Center, Minneapolis, MN, United States

The longitudinal and transverse relaxation time constants of blood are important parameters for MRI methods and biomedical research studies. However, these parameters can vary largely across subjects, and change significantly across developmental stages, with physiological states, and due to specific diseases, which has motivated in vivo measurements of these parameters. We implemented a fast method for simultaneous in vivo measurements of blood T1 and T2. The study results suggest that the in vivo measurements of blood T1 and T2 can be achieved in about 25 s using the implemented method.

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