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Abstract #2278

Validation of intrinsic actuation MR Elastography through a 1Hz experimental phantom system

Scott Gordon-Wylie1, Matthew McGarry1, Ligin Solamen1, Elijah Van Houten2, John Weaver1,3, and Keith Paulsen1,3

1Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, 2Mechanical Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada, 3Dartmouth Hitchcock Medical Center, Lebanon, NH, United States

A 1Hz MR elastography (MRE) phantom system is presented to validate the spatial accuracy of mechanical property images in intrinsic actuation MRE. A custom hydraulically driven actuator generated 1Hz shearing motions in gelatin phantoms with stiff inclusions which were measured using a retrospectively gated QFLOW sequence on a 3T Philips Achieva MRI. Maps of the octahedral shear strain showed low strain in stiff inclusions, and high strains in areas of stress concentrations, as expected from theory. Shear modulus maps computed by a viscoelastic nonlinear inversion MRE algorithm were spatially accurate, and identified the correct stiffness contrast of phantom components.

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