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Abstract #2280

Accuracy and precision of Synthetic MRI

Gabriel Mangeat1, Russell Ouellette2,3, Marcel Warntjes4,5, Michael Plattén2,3, Love Engström Nordin6,7, Nikola Stikov1,8, Tobias Granberg2,3, and Julien Cohen-Adad1,9

1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 3Division of Neuroradiology, Department of Radiology, Karolinska University Hospital, Stockholm, Sweden, 4Center for Medical Imaging Science and Visualization, CMIV, Linköping, Sweden, 5SyntheticMR, Linköping, Sweden, 6Department of Diagnostic Medical Physics, Karolinska University Hospital, Stockholm, Sweden, 7Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden, 8Montreal Health Institute, Montreal, QC, Canada, 9Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada

Synthetic MRI (SyMRI) provides quantitative PD, T1 and T2 maps via a rapid single-volume acquisition. Here, we aim to validate the precision and accuracy of SyMRI quantification by performing five scan re-scans, at two field strengths, of the quantitative NIST phantom and one control subject. Results show a good accuracy of T1 and T2 quantification at 3T, and a very good precision of all the phantom and subject measurements at 1.5T and 3T (95% confidence intervals width are respectively lower than 6% and 4%, of the measured value). This study brings confidence in comparing SyMRI quantitative measurements across subjects or time.

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