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Abstract #2294

Incidental magnetization transfer in qMRI: effects of multi-slice imaging with mixed-TSE.

Ning HUA1, Mitchell Horn1, Adam Aakil1, Stephan Anderson2, and Hernan Jara1

1Boston University, Boston, MA, United States, 2Boston Medical Center, Boston, MA, United States

Purpose: To evaluate the effect of inherent and incidental magnetization transfer (MT) on T1 and T2 measurements when using the mixed turbo spin echo sequence (mixed-TSE). Methods: mixed-TSE was applied to a phantom of 1-5% agarose gel. The levels of the MT effects were induced and controlled by varying the number of slices per acquisition package. Results: T1 values were underestimated in multi-slice mixed-TSE. No obvious trend was observed for T2 measurements. Conclusion: mixed-TSE is powerful and efficient tool for qMRI, yet caution should be taken when interpreting the derived T1 values because of MT effects.

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