Meeting Banner
Abstract #2298

Cerebrovascular function in the middle cerebral artery measured using the cardiac-induced inflow effect on fast echo-planar imaging.

Joseph Whittaker1, Patrick Liebig2, Fabrizio Fasano3, Marcello Venzi1, Robin Heidemann2, and Kevin Murphy1

1School of Physics and Astronomy, Cardiff University Brain Research Imgaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Healthcare Ltd, Camberly, United Kingdom

We demonstrate that cardiac-induced pulsatile flow-related signal enhancement in fast EPI provides a dynamic assessment of cerebrovascular function in the brain’s large feeding arteries. We show that cardiac pulsatile waveforms, derived from magnitude data taken at the site of the middle cerebral artery, are attenuated at longer TRs, suggesting they are related to pulsatile flow rather than volume changes. The same waveforms are modulated by a global flow-increasing hypercapnic challenge, showing that this endogenous signal contrast can be useful for exploring dynamic cerebrovascular function. We propose that a multi-shot segmented EPI approach will further increase this signal contrast.

This abstract and the presentation materials are available to members only; a login is required.

Join Here