Mice have well-developed olfactory systems, and the odor response throughout the mouse whole brain is an important target of olfactory research. We previously applied independent component analysis (ICA), which identifies periodically activated regions, to detect BOLD responses from odor-stimulated mice. In this study, we successfully discriminated olfactory responses from different odors, isoamyl acetate and musocone, in the mouse whole brain, using the BOLD-ICA method. In addition, we investigated the effects of urethane and medetomidine anesthetics on the olfactory responses. This study demonstrated the utility of the BOLD-ICA method to trace the real-time activation of the mouse whole brain.
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