Abstract #2312

BOLD-fMRI evaluation of different types of analgesic agents on allodynia-specific pain in a rat chronic pain model

Mikio Sameshima¹, Naoya Yuzuriha¹, Sosuke Yoshinaga¹, Soichiro Ezaki¹, Norihito Ishida¹, Mitsuhiro Takeda¹, Yuya Terashima², Etsuko Toda², Kouji Matsushima², and Hiroaki Terasawa¹

¹Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ²Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

The aims of this study are to reveal the underlying inhibitory mechanism of a compound against the chemokine signal, based on targeted protein structures, and to evaluate the analgesic effect on allodynia-specific responses in a rat chronic pain model, with our BOLD-fMRI-based pain evaluation system using a green laser. An NMR titration analysis demonstrated that the compound strongly binds to the chemokine receptor-binding protein. BOLD-fMRI revealed that the allodynia-specific responses were suppressed by the administration of the compound, in a similar manner to the existing analgesic, pregabalin, with a completely different mechanism of action from that of the compound.

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