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Abstract #2312

BOLD-fMRI evaluation of different types of analgesic agents on allodynia-specific pain in a rat chronic pain model

Mikio Sameshima1, Naoya Yuzuriha1, Sosuke Yoshinaga1, Soichiro Ezaki1, Norihito Ishida1, Mitsuhiro Takeda1, Yuya Terashima2, Etsuko Toda2, Kouji Matsushima2, and Hiroaki Terasawa1

1Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 2Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

The aims of this study are to reveal the underlying inhibitory mechanism of a compound against the chemokine signal, based on targeted protein structures, and to evaluate the analgesic effect on allodynia-specific responses in a rat chronic pain model, with our BOLD-fMRI-based pain evaluation system using a green laser. An NMR titration analysis demonstrated that the compound strongly binds to the chemokine receptor-binding protein. BOLD-fMRI revealed that the allodynia-specific responses were suppressed by the administration of the compound, in a similar manner to the existing analgesic, pregabalin, with a completely different mechanism of action from that of the compound.

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