Abstract #2321

Approximation of 1H MRS glutamate from fMRI hemodynamic response function

Rangaprakash Deshpande^1,2, Gopikrishna Deshpande^2,3,4, Reza Tadayonnejad¹, Joseph O’Neill¹, and Jamie D. Feusner¹

¹Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ³Department of Psychology, Auburn University, Auburn, AL, United States, ⁴Alabama Advanced Imaging Consortium, Auburn University and University of Alabama Birmingham, Auburn, AL, United States

Functional MRI is a blood-based marker of neural activity. The transfer function relating the two is the hemodynamic response function (HRF), which varies across both brain regions and individuals. It is traditionally considered a confound in fMRI analysis; however, the underlying biophysics suggests that HRF might in part reflect local neurochemical substrates, specifically glutamate, GABA and serotonin. Here, we found evidence that HRF shape is associated with, and predictive of, ¹H MRS glutamate in thalamus. These results open the possibility of approximating neurochemical concentrations using resting-state fMRI. Future studies could validate this in an independent and larger sample.

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