To get further insights into sustained and gender-dependent neurobiological effects of ketamine, an N-methyl-D-aspartate blocker carrying antidepressant and addictive properties, we investigated the resting-state functional connectivity (FC) in female and male rats 24 hours after a subanesthetic dose of ketamine. Ketamine tended to suppress FC between several brain regions such as hippocampus - medial prefrontal cortex and caudate putamen - medial prefrontal cortex. Significant interactions between treatment and gender were also observed. These observations shed light on the mechanisms underlying the complex neurobiological effects produced by ketamine.
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