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Abstract #2352

Ketamine-induced modulation of functional connectivity in male and female rats

Jaakko Paasonen1, Leena Penna2, Tomi Rantamäki2, and Olli Gröhn1

1A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Department of Biosciences, University of Helsinki, Helsinki, Finland

To get further insights into sustained and gender-dependent neurobiological effects of ketamine, an N-methyl-D-aspartate blocker carrying antidepressant and addictive properties, we investigated the resting-state functional connectivity (FC) in female and male rats 24 hours after a subanesthetic dose of ketamine. Ketamine tended to suppress FC between several brain regions such as hippocampus - medial prefrontal cortex and caudate putamen - medial prefrontal cortex. Significant interactions between treatment and gender were also observed. These observations shed light on the mechanisms underlying the complex neurobiological effects produced by ketamine.

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