In the present study, we used an emotional anticipation paradigm with functional magnetic resonance imaging (fMRI) to examine the anticipation processing of uncertain threat in anxious individuals by employing brain activation and general psychophysiological interactions (gPPI) analysis. Our findings show altered activations in dmPFC, precuneus, thalamus, and MTG; impaired connections of dmPFC-vmPFC, precuneus-FPN, precuneus-MTG, and precuneus-PHA during anticipation of uncertain threat in anxious individuals, which may be involved in estimation of, perception of, and emotional reactions to uncertain threat. All of these altered neural patterns may together contribute to pathology of anxiety. Our study also provides a new insight for neural and behavioral treatments focusing on the dmPFC-vmPFC circuit that underlies uncertainty estimation and emotion regulation in anxiety-related disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords