The utility of VASO to study disease-related alterations in CBV is demonstrated. Manipulation of baseline CBV with hypercapnia mimicking arteriolar disease states produces a change in dynamic coupling of BOLD and CBV visual evoked responses. Although no significant changes in signal amplitude were detected, the expected trend for amplitude reduction was observed in the VASO signals with increasing CO2 levels. The time-to-peak of BOLD responses lengthens but CBV peak times, being longer at baseline, remain the same. This study indicates that combining VASO and BOLD contrasts can be sensitive enough to investigate the consequences of patho-physiological changes in baseline CBV.
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