Meeting Banner
Abstract #2377

Hypercapnic manipulation of baseline blood volume alters coupling between BOLD and CBV visual responses

Marcello Venzi1, Joseph Whittaker1, Jessica Steventon1, Laurentius Huber2, Harald Möller3, and Kevin Murphy1

1School of Physics and Astronomy, Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 2SFIM, NIMH, Bethesda, MD, United States, 3Max-Planck-Institut für Kognitions- und Neurowissenschaften, Leipzig, Germany

The utility of VASO to study disease-related alterations in CBV is demonstrated. Manipulation of baseline CBV with hypercapnia mimicking arteriolar disease states produces a change in dynamic coupling of BOLD and CBV visual evoked responses. Although no significant changes in signal amplitude were detected, the expected trend for amplitude reduction was observed in the VASO signals with increasing CO2 levels. The time-to-peak of BOLD responses lengthens but CBV peak times, being longer at baseline, remain the same. This study indicates that combining VASO and BOLD contrasts can be sensitive enough to investigate the consequences of patho-physiological changes in baseline CBV.

This abstract and the presentation materials are available to members only; a login is required.

Join Here