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Abstract #2382

Mouse BOLD fMRI at 15.2 T: Detection of the entire somatosensory pathway including thalamic nuclei

Won Beom Jung1,2, Hyun-Ji Shim1,3, Sangwoo Kim1, and Seong-Gi Kim1,2,3

1Cener for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 3Department of Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea

BOLD-functional MRI is a useful tool to identify the brain function and to examine the functional effects on development, recovery, and reorganization. The most common stimulus-paradigm is the electrical forepaw/hindpaw stimulation to generate the evoked BOLD response. Although specific brain areas are involved in the somatosensory system, most studies in the anesthetized rodents have focused on the somatosensory cortex as it is difficult to detect activation in the subcortical areas. BOLD sensitivity is dependent on the field strength and affected by physiological condition under the anesthesia. Here, we demonstrated the thalamo-cortical BOLD response in mice under the ketamine-xylazine at 15.2T.

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