Abstract #2406

Alterations of Resting State fMRI Functional Connectivity in Hypercapnia

Yu-Chia Cheng¹, Teng-Chieh Cheng², Wen-Chau Wu³, Teng-Yi Huang⁴, Chao-Chun Lin⁵, Chia-Wei Lin⁵, Wu-Chung Shen⁵, and Yi-Jui Liu²

¹Master 's Program of Biomedical Informatics and Biomedical Engineering of Feng Chia University, Taichung City 407, Taiwan, ²Department of Automatic Control Engineering, Feng Chia University, Taichung City 407, Taiwan, ³Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, ⁴Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ⁵Department of Radiology, China Medical University Hospital, Taichung City 407, Taiwan

The purpose of this study is to explore the alterations of brain functional connectivity among different hypercapnia using resting-state functional magnetic resonance imaging (rs-fMRI). 10 healthy males were enrolled in this study. A high-resolution T1WI image and BOLD-EPI were performed by a 3 Tesla MR scanner. The CO2 gas mixture (air, 3%, 5% and 7%) was given at the different hypercanpic for each experiment. Our results show that the brain functional connectivity in resting state is changed in hypercapnia. FC is gradual reduction as the increased CO2 fraction in the most primary functional networks, expect the executive control network.

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