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Abstract #2414

A new analysis of resting state connectivity and graph theory reveals distinctive short-term modulations due to whisker stimulations in rats.

Silke Kreitz1,2, Benito de Celis Alonso3, Michael Uder2, and Andreas Hess1

1Institute for Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany, 2Department of Radiology, University Hospital of the Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, 3Faculty of Mathematical & Physical Sciences, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico

In this study we introduced a powerful new method to analyze resting state functional connectivity. The MSRA approach integrates classical seed based correlation and modern graph-theory. In comparison to two undirected graph-theoretical approaches, it resembles ICA components best and is characterized by its high specificity and reproducibility. In combination with an adaptation of the network based statistics to paired samples, it promises to be a powerful tool to investigate short term modulations of sensory stimuli related resting state connectivity and ultimately impact our understanding of basic brain functions like fear to higher functions such as plasticity, learning and memory.

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