Abstract #2426

Kurtosis as a potential tool to differentiate breast hematological malignancies from breast cancer

Mizue Suzuki¹, Masako Kataoka¹, Mami Iima¹, Shotaro Kanao¹, Kanae Kawai Miyake¹, Rena Sakaguchi¹, Ayami Ohno Kishimoto¹, Maya Honda¹, Tadakazu Kondo², Tatsuki Kataoka³, Takaki Sakurai³, Masakazu Toi⁴, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Since breast hematological malignancies show various image findings, it is not easy to differentiate them from breast cancer using conventional MRI. Non-Gaussian diffusion MRI is a relatively new method using multi b values from low to high, reflecting the interaction of water molecules with tissue features. We compared non-Gaussian parameters of breast hematological malignancies and breast cancer to investigate the advantage of non-Gaussian diffusion imaging. Our preliminary results suggest potential advantage of kurtosis as a marker of cellular structure and usefulness in differential diagnosis between breast hematological malignancies and breast cancer.

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