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Abstract #2448

Non-rigid motion correction for arterial spin labeled (ASL) perfusion imaging of the placenta using ANTs

Zhengjun Li1, Eileen Hwuang1, Jeffrey Duda2, Marta Vidorretta1, Nadav Schwartz3, John Detre1,2, Walter Witschey2, and Dylan Tisdall2

1Dept. of Neurology, University of Pennsylvania, Philadelphia, PA, United States, 2Dept. of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Dept. of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, United States

Non-rigid motion of the placenta due to maternal breathing and fetal movement is one of the main challenges in placental MRI. In this study, we evaluated non-rigid motion correction of the placenta during arterial spin labeled (ASL) perfusion imaging, using Advanced Normalization Tools (ANTs). The results showed that non-rigid motion correction with ANTs improved the resulting perfusion images as evidenced by reduced the residual power of control-label regression, increased the tSNR, and reduced the power of respiration in the signal.

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