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Abstract #2462

Pre-treatment DCE MRI predicts overall survival in patients with primary lung cancer

Wei Wu1, Daniel S Hippe2, Nina A Mayr3, William Yuh2, Liming Xia1, and Stephen R Bowen3

1Radiology, Tongji Medical college affiliated to Huazhong University of Science and Technology, Wuhan, China, 2Radiology, University of Washington, Seattle, WA, United States, 3Radiation Oncology, University of Washington, Seattle, WA, United States

We tested whether pre-treatment standard DCE MRI imaging and clinical features can predict overall survival (OS) of 37 patients with primary lung cancer. Primary tumor volume (hazard ratio [HR] = 3.19 per 1-SD increase, P=0.001) and minimum intensity of the peak enhancement phase on DCE MRI (HR = 0.45, P=0.012) were significant predictors of OS on univariate Cox regression analysis. Univariate primary tumor volume model (c-index = 0.76, P=0.002) and multivariate LASSO Cox models based on DCE MRI features (c-index = 0.69, P=0.046) were positive predictors for OS with no statistically significant difference in performance (P=0.36).

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