Abstract #2467

Contributions of Large Versus Small Airways to MRI Ventilation Heterogeneity in Asthmatics

Rachel L Eddy^1,2, Heather M Young^1,2, Andrea Kassay^1,2, Dante PI Capaldi^1,2, Sarah Svenningsen^1,3, David G McCormack⁴, and Grace Parraga^1,2

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Medicine, McMaster University, Hamilton, ON, Canada, ⁴Medicine, Division of Respirology, Western University, London, ON, Canada

Pulmonary functional MRI identifies the exact location of functional abnormalities within the asthmatic lung, however the relative contributions of large and small airways to ventilation heterogeneity in a given patient are unknown. Here, we differentiated hyperpolarized noble gas MRI ventilation into regions corresponding to the large and small airways using patient-specific airway trees and calculated the ventilation defect percent (VDP) related to large and small airways independently. The classification of small and large airway VDP may help with clinical treatment decisions for individualized therapies.

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