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Abstract #2469

Dynamic contrast-enhanced MRI in the lung – evaluation of measures of pulmonary oedema and pulmonary endothelial permeability in healthy subjects and patients with chronic heart failure

Alexandra R. Morgan1, Joseph Cheriyan2,3,4, Caleb Roberts5, Martin J. Graves4, Ilse Patterson4, Rhys A. Slough4, Rosemary Schroyer6, Disala Fernando2, Linda Henderson7, Subramanya Kumar2, Geoffrey J.M. Parker5,8, Dennis Sprecher7, and Robert L. Janiczek1

1GSK, Stevenage, United Kingdom, 2GSK Clinical Unit, Cambridge, United Kingdom, 3Experimental Medicine & Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom, 4Cambridge University Hospitals, Cambridge, United Kingdom, 5Bioxydyn Ltd, Manchester, United Kingdom, 6GSK, Collegeville, PA, United States, 7GSK, King of Prussia, PA, United States, 8Centre for Imaging Sciences, The University of Manchester, Manchester, United Kingdom

MRI has previously demonstrated increased lung water content in patients with heart failure (HF), but has not yet been used to distinguish between intravascular and extravascular water in these patients. This study evaluated dynamic contrast-enhanced MRI (DCE-MRI) for measuring pulmonary oedema and endothelial permeability in healthy volunteers (HV) and chronic HF patients at rest and post-exercise. DCE-MRI showed a redistribution of lung water towards the interstitial space in chronic HF, as compared to HV, suggesting this method may have value as a novel endpoint for dose-ranging and proof-of-mechanism studies in chronic HF. No exercise-induced change was seen in either group.

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