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Abstract #2488

Assessment of Colonic Motility Using Magnetic Resonance Imaging: Reproducibility of a Macrogol Challenge

Victoria Wilkinson-Smith1,2, Alex Menys3, Christopher Bradley2,4, Maura Corsetti1,2, Luca Marciani1,2, David Atkinson5, Carol Coupland6, Stuart Taylor5, Penny Gowland4, Robin Spiller1,2, and Caroline Hoad 2,4

1Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, 2National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 3Motilent Ltd, London, United Kingdom, 4Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 5Centre for Medical Imaging, University College London, London, United Kingdom, 6Division of Primary Care, University of Nottingham, Nottingham, United Kingdom

This study assessed the reproducibility of a previously developed diagnostic test using a macrogol stimulus and MRI measures to assess colonic motility. This test was performed twice on healthy volunteers and the results were compared. The data showed some variability across visits representing both variability in baseline data and the physiological response of the colon to the stimulus. Correlation data suggested that although intra-subject variability existed the maximum measured MRI parameters all increased post stimulus. This colonic stimulus test allows us greater insight into potential pathologies behind GI disorders and as such may be of value here.

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