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Abstract #2545

MRI in the evaluation of liver involvement in pediatric patients with cystic fibrosis

Katherine J Carey1,2, Scott B Reeder1,2, Mark Kliewer 2, R. Paul Guillerman 3, Diego Hernando1,2, and Scott K Nagle2

1Medical Physics, University of Wisconsin, Madison, WI, United States, 2Radiology, University of Wisconsin, Madison, WI, United States, 3Radiology, Texas Children's Hospital, Houston, TX, United States

In this prospective study of 15 pediatric cystic fibrosis subjects, we show that non-sedated comprehensive quantitative liver MRI is feasible. Furthermore, free-breathing 2D IDEAL IQ outperformed breath-held 3D IDEAL IQ in both image quality and repeatability of proton density fat fraction. Short term 1-2 week repeatability of MR elastography stiffness measurements were comparable with ultrasound elastography. Quantitative liver MRI in the pediatric cystic fibrosis population offers the ability to visualize structure and quantify hepatic steatosis and liver stiffness in a single exam.

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