Multi parametric magnetic resonance imaging for the detection of prostate cancer: combination of T2-weighted, diffusion tensor imaging and magnetic resonance spectroscopic imaging
Neda Gholizadeh1, Peter B Greer2,3, John Simpson2,3, Jim Denham4, Peter Lau5,6, and Saadallah Ramadan1,6
1Health Science, The University of Newcastle, Newcastle, Australia, 2Radiation oncology, Calvary Mater Newcastle, Newcastle, Australia, 3Medical Physics, The University of Newcastle, Newcastle, Australia, 4Radiation oncology, calvary mater newcastle, Newcastle, Australia, 5Radiology, Calvary Mater Newcastle, Newcastle, Australia, 6Imaging Centre, Hunter Medical Research Institute (HMRI), Newcastle, Australia
The aim of this study was to determine the diagnostic performance of mp-MRI using T2WI, DWI, DTI and MRSI for prostate cancer patients with various Gleason scores. mp-MRI using T2WI, DWI, DTI and MRSI on 12 prostate cancer patients. The area under receiver operating characteristic (ROC) curve of T2WI+DWI and T2WI+DWI+DTI+MRSI images were generated and used to evaluate the performance of mp-MRI for discriminating cancer and healthy regions. Our results suggest that mp-MRI using DWI, DTI and MRSI in combination with structural T2WI improve performance for discrimination of cancer and healthy prostate tissues.
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