Abstract #2571

Ex vivo ultra-high-field 9.4-Tesla magnetic resonance elastography (MRE) in comparison to whole-mount pathology for improved prostate cancer diagnostics.

Rolf Otto Reiter^1,2, Shreyan Majumdar¹, Steven Kearney¹, Thomas Royston¹, Brandon Caldwell³, Rong-Wen Tain⁴, Kejia Cai⁴, Cristian Luciano¹, Andre Kajdacsy-Balla⁵, Winnie Mar⁴, Michael Abern³, and Dieter Klatt¹

¹Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, ³Department of Urology, University of Illinois at Chicago, Chicago, IL, United States, ⁴Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, ⁵Department of Pathology, University of Illinois at Chicago, Chicago, IL, United States

Despite the success of multiparametric magnetic resonance imaging (mpMRI) for the assessment of prostate cancer, it suffers from limitations such as a moderate inter-reader reliability and sub-optimal diagnostic accuracy. This is the first study for the assessment of 6 human prostate specimens without pathology fixation or prior radiation therapy using ex vivo 9.4-Tesla magnetic resonance elastography (MRE). Using whole-mount pathology as a reference, preliminary results show a sensitivity and specificity of 86 % and 52 %, respectively. MRE has the potential to improve the differentiation of benign prostatic hyperplasia nodules from malignant lesions, which is a known limitation of mpMRI.

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