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Abstract #2591

Inter reader agreement for liver Magnetic Resonance Elastography region-of-interest (ROI)-size, -overlap, -placement, and stiffness estimation in adults in a clinical trial

Adrija Mamidipalli1, Walter C. Henderson1, Jonathan C. Hooker1, Tanya Wolfson2, Yesenia Covarrubias1, Anthony Gamst2, Nikolaus Szeverenyi1, Gavin Hamilton1, Rohit Loomba3, and Claude B. Sirlin1

1Liver Imaging Group, Radiology, UCSD, San Diego, CA, United States, 2Computational and Applied Statistics Laboratory, UCSD, San Diego, CA, United States, 3NAFLD Research Center, Division of Gastroenterology, Department of Medicine, UCSD, San Diego, CA, United States

MR elastography (MRE) is an established technique for the non-invasive assessment of hepatic stiffness and fibrosis, and is commonly performed using a gradient-echo-acquisition of four slices through the widest portion of the liver. The mean liver-stiffness is calculated as the average of the ROI pixel values over all four stiffness map slices. Identification (drawing) of these ROIs is subjective, relying on reader judgment to assess the wave-quality. This study examines the inter-reader agreement of MRE-ROI-size, overlap and placement, and how they affect the MRE shear-stiffness values in adults with known or suspected nonalcoholic fatty liver disease.

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