Abstract #2647

Crossed cerebellar diaschisis: diagnostic & prognostic value of BOLD fMRI cerebrovascular reactivity

Marco Piccirelli¹, Martina Sebök², Christiaan van Niftrik², Oliver Bozinov², Susanne Wegener³, Giuseppe Esposito², Athina Pangalu¹, Antonios Valavanis¹, Alfred Buck⁴, Andreas Luft³, Luca Regli², and Jorn Fierstra²

¹Neuroradiology, University Hospital Zurich, Zurich, Switzerland, ²Neurosurgery, University Hospital Zurich, Zurich, Switzerland, ³Neurology, University Hospital Zurich, Zurich, Switzerland, ⁴Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland

Crossed cerebellar diaschisis (CCD) is associated with poorer stroke outcome and is traditionally measured with [15O]-H2O-PET.

BOLD-CVR can detect CCD with high specificity and sensitivity. Furthermore, CCD subjects identified with BOLD-CVR also had a poorer clinical status at baseline and at three months follow-up. These encouraging results suggest that BOLD-CVR might be considered as a diagnostic and prognostic test for CCD subjects, comparable to the gold standard [15O]-H2O-PET – but without the ~1mSv radiation dose.

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