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Abstract #2674

Development of a spiral spin- and gradient-echo (spiral-SAGE) approach for improved dynamic contrast neuroimaging

Ashley M. Stokes1, Ryan K. Robison2,3, Ashley G. Anderson III2, James G. Pipe2, and C. Chad Quarles1

1Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, 2Magnetic Resonance Technology Design Group, Barrow Neurological Institute, Phoenix, AZ, United States, 3Phoenix Children's Hospital, Phoenix, AZ, United States

The purpose of this study is to develop a spiral-based combined spin- and gradient-echo (spiral-SAGE) pulse sequence for simultaneous dynamic contrast-enhanced (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI). Using this sequence, we obtained gradient-echo TEs of 1.69 and 26 ms, a SE TE of 87.72 ms, with a TR of 1663 ms. Using an iterative SENSE reconstruction followed by deblurring, spiral-induced image artifacts were minimized. Comparison of spiral-SAGE images with conventional EPI-SAGE images illustrates substantial improvements in image distortion and image intensity variations. Spiral-SAGE provides a significant improvement for the assessment of perfusion and permeability in various neuropathologies.

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