Single-shot echo-planar imaging (EPI) is usually used in diffusion-weighted imaging (DWI); however, it is difficult to apply to examining the entire brain because of image distortion due to susceptibility inhomogeneity. In addition, multi-shot imaging, in which image distortion is relatively small, is affected by pulsation artifacts and aliasing. We propose a multi-shot spiral method in which a spiral trajectory is divided in the radial direction. DWI studies were performed on the brain of a healthy volunteer. The proposed method could sample k-space data for each shot without aliasing, and sufficient correction for pulsation artifacts could be obtained.