We have developed a simple method for EPI Nyquist ghosting artifacts removal. Our technique borrows the idea of GRAPPA, and extracts a non-biased kernel from imperfect multichannel EPI data to correct the odd-even line inconsistency. We have demonstrated both in-vivo and in-vitro that this strategy can significantly reduce Nyquist ghosts. The proposed method is quite simple and can be conveniently used with many current EPI correction techniques to generate ghosting-free images.
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