Abstract #2698

Multi-compartment relaxation-compensated IVIM imaging of the human brain

Anna Scherman Rydhög¹, Ofer Pasternak², Freddy Ståhlberg^1,3,4, Ronnie Wirestam¹, Linda Knutsson^1,5, and André Ahlgren¹

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Departments of Psychiatry and Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Diagnostic Radiology, Lund University, Lund, Sweden, ⁴Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁵The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

In conventional intravoxel incoherent motion (IVIM) imaging, the blood fraction is estimated using a two-compartment model (blood and tissue). However, blood fraction estimation is hampered by cerebrospinal fluid (CSF) contamination and tissue-dependent relaxation times. We propose a three-compartment model (blood, tissue, CSF), which accounts for compartment-specific diffusion and relaxation properties. Estimation of gray and white matter blood fractions using this model is demonstrated with in-vivo human data of variable diffusion weightings, echo times and inversion times. In comparison with two-compartment models (with and without relaxation), the proposed three-compartment model yielded lower estimates of the blood fraction, suggesting a better separation from CSF.

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