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Abstract #2702

Respiratory-Gated B0 Field Stabilisation for High Resolution Mouse Brain Imaging

Paul Kinchesh1, Stuart Gilchrist1, Niloufar Zarghami1, Alexandre A Khrapitchev1, Nicola R Sibson1, and Sean Smart1

1CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

The echoes of a 3D multi gradient echo (MGE) scan are typically combined for detection of USPIO and MPIO. The echo combination requires B0 to be constant throughout the scan to achieve good image fidelity at high resolution. A navigator acquisition embedded in the MGE scan maintains the MR steady state and enables a real-time adaptive B0 correction. It is demonstrated that a respiratory-gated correction scheme outperforms ungated correction in mouse brain for the detection of micron sized iron-oxide particles coupled with anti-vascular cell adhesion molecule antibody (VCAM-MPIO) to identify inflammation in vessels.

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