Simultaneous Multi-Contrast (SMC) Imaging enables a synchronous acquisition of multiple image contrasts within one measurement. The technique reduces patient examination times and facilitates accurate image registration between contrasts. Previous work used readout-segmented EPI (rs-EPI) to perform high-resolution, navigator-corrected, diffusion-weighted imaging simultaneously with a T2*-weighted acquisition. This combination of contrasts has clinical significance in acute stroke. These previous studies did not use in-plane acceleration to reduce spatial distortion caused by the EPI readout. This study introduces an updated version of the SMC technique that incorporates in-plane acceleration with GRAPPA to allow an improved image quality for future clinical studies.
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