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Abstract #2743

Optimization of Asymmetric Spin Echo MRI for Oxygen Extraction Fraction Mapping in the Brain and Initial Experience with Moya-Moya Patients

Dharmesh Tailor1, John J Lee2, Hongyu An3, and Colin Derdeyn4

1Radiology, Florida Hospital & University of Central Florida School of Medicine, Orlando, FL, United States, 2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States, 3Washington University School of Medicine, St. Louis, MO, United States, 4University of Iowa School of Medicine, Iowa City, IA, United States

Asymmetric Spin Echo (ASE) MRI has been previously applied for quantitative cerebral oxygen extraction mapping. In this study we optimize this technique using O-15 PET as a gold standard for oxygen extraction fraction (OEF) quantitation and apply the optimized ASE approach for studying brain lesions in Moya-Moya patients. Results suggest that optimized OEF maps from ASE MRI have the potential to detect brain lesions unseen with conventional MRI sequences. These lesions detected by ASE appear to provide information that is statistically independent from the information provided by conventional MRI approaches.

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