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Abstract #2751

Radiomics using multi parametric MRI for pre-treatment prediction of complete response to neo-adjuvant treatment in locally advanced rectal cancer

Stefano Trebeschi1, Joost J. M. van Griethuysen1, Doenja M. J. Lambregts1, Max J Lahaye1, Frans C. H. Bakers2, Roy F.A. Vliegen3, Emile Voest4, Regina G.H. Beets-Tan1, and Hugo J.W.L. Aerts5

1Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands, 2Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 3Radiology, Zuyderland Medical Center Heerlen, Heerlen, Netherlands, 4Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands, 5Radiation Oncology and Radiology, Dana Farber Cancer Institute, Boston, MA, United States

Aim of this investigation was to assess the predictive value of MR Radiomics as predictive biomarker for locally advanced rectal carcinoma. Through univariate analysis and unsupervised biclustering we found significant associations between diffusion radiomic textures and complete response in a multi-center cohort. The results suggest the viability of Radiomics as biomarker and puts emphasis on image quality.

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