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Abstract #2754

Rapid whole brain qMT imaging with inter-slice MT effects and database-driven fitting approach

Jae-Woong Kim1, Sul-Li Lee1, Seung Hong Choi2, and Sung-Hong Park1

1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea

Quantitative magnetization transfer (qMT) imaging provides unique tissue contrast, but suffers from prolonged scan time and processing time. The current study suggests inter-slice MT acquisition and database-driven qMT parameter fitting in order to mitigate the problems. Inter-slice scanning takes advantage of incidental MT effects, and thus does not require separate MT preparation. It enabled us to complete the whole brain data acquisition within a clinically reasonable scan time of ~10 min. The employment of pre-defined database also greatly reduced the qMT processing time, while revealing consistent qMT maps compared to those from the conventional method. The proposed database-driven inter-slice qMT method can be a promising alternative of qMT imaging.

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