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Abstract #2760

Multi-Parameter Mapping with 500 µm Resolution Using a Flexible 23-Channel RF Coil

Kerrin J Pine1, Lenka Vaculciakova1, Evgeniya Kirilina1, Nico Scherf1, and Nikolaus Weiskopf1

1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

To better understand the human brain’s microstructure, there is a need for in-vivo myelin and iron mapping methods which have sufficient resolution to map mesoscopic intra-cortical structures (e.g. lamina). However, resolution is critically SNR-limited. We show that by using a mechanically flexible RF coil array which conforms to the subject’s own individual skull shape, sufficient SNR is gained to map the main MR contrast parameters and the line of Gennari within the superficial primary visual cortex. The work demonstrates the feasibility of laminar analysis of myelination at widely available modest field strengths.

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