Abstract #2867

A Tailored Functional Form for Increased Accuracy in CEST B1 Calibration Curves

Abigail T.J. Cember^1,2, Hari Hariharan^2,3, and Ravinder Reddy^2,3

¹Graduate Group in Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ²Center for Magnetic Resonance and Optical Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Correction for the amplitude of B₁(RF pulse) in CEST experiments is currently done using calibration curves fitted ad hoc with polynomial functions. We have previously found that these polynomial-based correction curves sometimes produce unreasonable results, especially in measurements with large B₁ variation. Here, we use Bloch-McConnell simulations of CEST as a function of B₁ strength to demonstrate a new, Lorentzian-type functional form and fitting strategy, expected to lead to an increase in both accuracy and precision in processing of CEST data.

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