The development of gradual and diffuse myocardial fibrosis is a key pathology in muscular dystrophy and it is possible that extracellular volume (ECV) measurement may be a useful biomarker. Thirteen participants with muscular dystrophy and ten healthy controls were recruited to undergo cardiac MRI, including cardiac tagging, LGE and ECV measurement to determine whether significant global or local differences in ECV could be detected, and their relationship to cardiac dysfunction as indicated by cine imaging and cardiac tagging. Global ECV was not different but there were significant segmental differences between muscular dystrophy and controls.
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