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Abstract #2928

4D Flow MRI-Based Aortic Pulse Wave Velocity: Systematic Analysis of the Impact of Temporal Resolution on Estimation in Patients with Aortic Atherosclerosis and Age-matched Controls

Kelly Jarvis1, Alireza Vali1, Shyam Prabhakaran2, Jeremy D. Collins1, and Michael Markl1

1Radiology, Northwestern University, Chicago, IL, United States, 2Neurology, Northwestern University, Chicago, IL, United States

Elevated pulse wave velocity (PWV) is a measure of aortic stiffness and an indicator of cardiovascular disease. Pulse waves propagate quickly along the aorta and high-temporal resolution measurement of velocity data with full spatial coverage is needed to improve the precision of PWV estimation. This study used high-temporal resolution 4D flow MRI to assess PWV and investigate the impact of temporal resolution on PWV estimation methods (i.e. time-to-foot and cross-correlation) in patients with known atherosclerosis. The findings suggest that using cross-correlation to estimate the time-delay between flow waveforms is optimal, particularly at inferior temporal resolutions.

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