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Abstract #2959

Oxygenation-sensitive cardiovascular magnetic resonance in Hypertensive Heart Disease with LVMH and Non-LVMH:Insight from altered mechanics and cardiac BOLD imaging

Binghua Chen1, Rui Wu1, Dong-Aolei An1, Ruo-Yang Shi1, Qiu-Ying Yao1, Qing Lu1, Jiani Hu2, Meng Jiang3, Weibo Chen4, James Deen2, Ankush Chandra2, Jian-Rong Xu1, and Lian-Ming Wu1

1Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Wayne State University, Detroit, MI, United States, 3Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 4Philips Healthcare, Shanghai, China

According to our study findings, BOLD MRI detected greater deoxygenated hemoglobin in HTN LVMH(measured by T2* BOLD MRI)compared with HTN non-LVMH and control groups. Lower T2* BOLD MRI values were associated with higher ECV values and correlated with reductions in circumferential and longitudinal strain, strain rate and displacement. Higher LVMI was associated with an increase in ECV and nativeT1, and a decrease inT2* BOLD MRI values. To our knowledge, this is the first study to assess the influence of myocardial oxygenation on cardiac function in hypertensive patients by applying combined T2* BOLD MRI, T1mapping and strain analysis. Assessing myocardial capillary oxygenation by BOLD MRI relies on the measurement of BOLD MRI relaxation time through endogenous contrast of deoxygenated hemoglobin. Myocardial microvascular oxygenation could reflect a balance or imbalance between oxygen supply and demand.

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