Myocardial perfusion imaging is recommended for ischaemia testing in patients although spatial coverage is limited to 3 slices in clinical practice. Simultaneous Multi Slice (SMS) imaging combined with iterative reconstruction was evaluated to provide greater heart coverage with minimal signal-to-noise penalty. 8 patients underwent two contrast enhanced dynamic perfusion scans at rest to compare the standard 3 slice with the SMS 6 slice protocol. Subjective image quality was found to be comparable to a standard 3 slice approach. This technique may have clinical utility in patients with suspected coronary artery disease through detection of ischaemia with greater heart coverage.