Abstract #2968

Left Atrial Surface Strain from Cine MRI Data in Patients with Mitral Regurgitation

Xiaoxia Zhang^1,2, Himanshu Gupta³, James Davis³, Steven G. Lloyd³, Louis Dell’Italia³, and Thomas S. Denney Jr.^1,2

¹Auburn University MRI Research Center, Auburn University, Auburn, AL, United States, ²Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ³Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States

Mitral regurgitation (MR) is a common form of valvular disease where degeneration of the mitral valve causes blood from the left ventricle to be regurgitated into the left atrium (LA). For some MR patients, surgery to repair or replace the mitral valve is an option, but it can be difficult to determine when to do the surgery. Volumetric remodeling in the left atrium in MR patients has been reported, and could precede remodeling of the left ventricle (LV) and damage to the LV wall. Here, we investigate changes in endocardial surface strain in the LA in patients with MR compared to normal. Changes in LA volume and deformation may be useful in determining the severity and chronicity of valvular regurgitation and have clinical potentials in optimizing surgery timing and patient management.

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