Abstract #2980

Quantitative Classification of Atherosclerotic Plaque Compositions in Carotid Arteries: An in vivo T1 Mapping Study

Huiyu Qiao¹, Haikun Qi¹, Dongye Li^1,2, Dongxiang Xu³, Huijun Chen¹, Chun Yuan^1,3, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Center for Brain Disorders Research, Capital Medical University, Beijing, China, ³Department of Radiology, University of Washington, Seattle, WA, United States

This study sought to investigate the usefulness of in vivo T1 mapping in quantitative classification of compositions and vulnerability of carotid artery atherosclerotic plaques. We found that it is feasible to quantify the T1 values of atherosclerotic plaque compositions in carotid artery with in vivo T1 mapping. Significant differences in T1 values between fibrous tissue and other plaque compositions indicate that it is possible to classify plaque compositional features using T1 mapping. In addition, our findings of IPH and LRNC with significant different T1 values from other plaque compositions suggest the potential of T1 mapping in classification of plaque vulnerability.

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