Intracranial and extracranial atherosclerotic disease are major causes of ischemic stroke. Recently, an improved DANTE-prepared 3D variable-flip-angle turbo spin echo (SPACE) imaging method was developed for high resolution simultaneously imaging of intracranial and extracranial arterial vessel wall with enhanced cerebrospinal fluid suppression. The purpose of this study was to evaluate the scan-rescan, intra-and inter-observer reproducibility when using the method for comprehensive assessment of intracranial and extracranial vessel wall morphology. In conclusion, the improved 3D simultaneous vessel wall imaging technique provided good to excellent reproducibility for intracranial and extracranial arterial vessel wall measurements.
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