Abstract #3005

Preliminary Investigation of Extravascular Fluid Transport along Arterial Adventitia of Human Lower Extremity

Hongyi Li¹, Wentao Liu², Yang Fan³, Liang Xu⁴, Yupeng Cao^2,5, Fang Wang¹, Dong Han^2,5, and Min Chen⁴

¹Cardiology Division, Beijing Hospital, Beijing, China, ²CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, China, ³MR Research China, GE Healthcare, Beijing, China, ⁴Radiological department, Beijing Hospital, Beijing, China, ⁵School of Future Technology, University of Chinese Academy of Sciences, Beijing, China

Extravascular fluid transport have been reported both in human and animal studies during recent decades. Our previous work demonstrated a long-distance extravascular fluid transport which is consisted of oriented fibrous connective tissues in venous adventitia, arterial adventitia and dermis of amputated lower extremities. To further explore the pattern of fluid transport along lower extremity arteries, we implemented contrast enhanced MRI in volunteers and tracked the longitudinal contrast agent transportation. The periarterial regions near tibia showed high signal intensity after contrast agent administration suggest an unexplored extravascular fluid transport. This study may provide a novel diagnosis method of PAD.

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