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Abstract #3011

Association between Incompleteness of Circle of Willis and Carotid Vulenrable Atherosclerotic Plaques: A CARE-II Study

Changwu Zhou1, Chun Yuan2,3, Wei Wang1, Cheng Li4, and Xihai Zhao3

1Radiology, The affiliated hospital of YangZhou University, YangZhou, China, 2Department of Radiology, University of Washington, Washington, American Samoa, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 4Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China

The circle of Willis (COW) is an important intracranocervical collateral circulation system. We hypothesized that the integrity of COW may affect the characteristics of carotid plaques by influencing carotid hemodynamics. This study investigated the relationship between incompleteness of COW and the compositional features of atherosclerotic plaques in carotid arteries. We found that the incompleteness of circle of Willis is associated with vulnerability of carotid artery atherosclerotic plaques. Our findings suggest that integrity of circle of Willis may play a role in occurence of high risk plaque features, particularly intraplaque hemorrhage and fibrous cap rupture.

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