Abstract #3015

Cardiac MRI assessment of the effects of dietary Eicosapentaenoic acid (EPA) on the adverse cardiac consequences of sepsis in rat

Amidou Sissou Traore¹, Thibault Leger², Guilhem Pagès¹, Lucie Cassagnes^3,4, Azarnoush Kasra⁵, Jean-Marie Bonny¹, and Luc Demaison^2,6

¹UR270 QuaPA, INRA, Saint-Genès Champanelle, France, ²UNH, INRA, Clermont-Ferrand, France, ³Department of diagnostic and interventional radiology, Clermont Ferrand University Hospital, Clermont-Ferrand, France, ⁴IGT, Institut Pascal, UMR 6602, CNRS, Clermont-Ferrand, France, ⁵Heart Surgery Department, Clermont Ferrand University Hospital, Clermont-Ferrand, France, ⁶CRNH, Clermont Auvergne University, Clermont-Ferrand, France

Severe sepsis is one of the leading cause of death in the intensive care units (ICU) or in short time after discharge from ICU. Developing a rat model of early sepsis involving caecal ligation and puncture, we undertaken this cardiac MRI study to quantitatively assess myocardial function and the protective effect of dietary EPA. Our results showed that, in the exception of the rate of contraction, cardiac functions are less impacted in the early hyperdynamic phase of sepsis with no/or milder modulation of dietary EPA.

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